HYPERBARIC OXYGENATION IN THE TREATMENT OF LATE POSTRADIATION CYSTITIS

• Main Authors: O. B. Loran, L. A. Sinyakova, A. A. Mitrokhin, A. M. Plesovsky
• Format: Article
• Language: Russian
• Published: ABV-press 2014-07-01
• Series: Onkourologiâ
• Subjects: postradiation cystitis; radiotherapy; complications of radiotherapy; hyperbaric oxygenation; postradiation fibrosis
• Online Access: https://oncourology.abvpress.ru/oncur/article/view/157

Radiotherapy (RT) alone or in combination with other treatment modalities is widely used in the treatment of urological and gynecological cancers. Despite the fact that there is continuous technical improvement of equipment and RT procedures, the frequency of complications due to this treatment option remains high in the early and late periods and generally requires complex and long-term care. One of the leading pathogenetic mechanisms responsible for the development of these complications is vascular endothelial damage and hence decreased blood and oxygen supply to the tissues of pelvic organs. Postradiation cystitis is one of the commonest complications of RT. Among various treatment modalities for postradiation hemorrhagic cystitis, hyperbaric oxygenation yielded good results particularly in cases of ineffective standard treatments.