Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells

Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells

Transition from premalignant lesion to cancer cell highlights tumor initiation. Here, the authors use a model of K-Ras-initiated lung cancer to document two successive asymmetric divisions, each driven by mitotic polarization of key transcription factors, which lead to generation of initial cancer c...

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Main Authors: Yongqing Liu, Laura Siles, Xiaoqin Lu, Kevin C. Dean, Miriam Cuatrecasas, Antonio Postigo, Douglas C. Dean
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04663-1
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spelling doaj-df38bfb58c814b399b684abd35f652592021-05-11T10:01:46ZengNature Publishing GroupNature Communications2041-17232018-06-019111410.1038/s41467-018-04663-1Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cellsYongqing Liu0Laura Siles1Xiaoqin Lu2Kevin C. Dean3Miriam Cuatrecasas4Antonio Postigo5Douglas C. Dean6Molecular Targets Program, James Brown Cancer Center, University of Louisville Health Sciences CenterGroup of Transcriptional Regulation of Gene Expression, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERehdDepartment of Ophthalmology and Visual Sciences, University of Louisville Health Sciences CenterDepartment of Ophthalmology and Visual Sciences, University of Louisville Health Sciences CenterDepartment of Pathology, Centro de Diagnóstico Biomédico (CDB) Hospital Clínic, University of BarcelonaMolecular Targets Program, James Brown Cancer Center, University of Louisville Health Sciences CenterMolecular Targets Program, James Brown Cancer Center, University of Louisville Health Sciences CenterTransition from premalignant lesion to cancer cell highlights tumor initiation. Here, the authors use a model of K-Ras-initiated lung cancer to document two successive asymmetric divisions, each driven by mitotic polarization of key transcription factors, which lead to generation of initial cancer cells.https://doi.org/10.1038/s41467-018-04663-1
collection DOAJ
language English
format Article
sources DOAJ
author Yongqing Liu
Laura Siles
Xiaoqin Lu
Kevin C. Dean
Miriam Cuatrecasas
Antonio Postigo
Douglas C. Dean
spellingShingle Yongqing Liu
Laura Siles
Xiaoqin Lu
Kevin C. Dean
Miriam Cuatrecasas
Antonio Postigo
Douglas C. Dean
Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells
Nature Communications
author_facet Yongqing Liu
Laura Siles
Xiaoqin Lu
Kevin C. Dean
Miriam Cuatrecasas
Antonio Postigo
Douglas C. Dean
author_sort Yongqing Liu
title Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells
title_short Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells
title_full Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells
title_fullStr Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells
title_full_unstemmed Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells
title_sort mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-06-01
description Transition from premalignant lesion to cancer cell highlights tumor initiation. Here, the authors use a model of K-Ras-initiated lung cancer to document two successive asymmetric divisions, each driven by mitotic polarization of key transcription factors, which lead to generation of initial cancer cells.
url https://doi.org/10.1038/s41467-018-04663-1
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AT laurasiles mitoticpolarizationoftranscriptionfactorsduringasymmetricdivisionestablishesfateofformingcancercells
AT xiaoqinlu mitoticpolarizationoftranscriptionfactorsduringasymmetricdivisionestablishesfateofformingcancercells
AT kevincdean mitoticpolarizationoftranscriptionfactorsduringasymmetricdivisionestablishesfateofformingcancercells
AT miriamcuatrecasas mitoticpolarizationoftranscriptionfactorsduringasymmetricdivisionestablishesfateofformingcancercells
AT antoniopostigo mitoticpolarizationoftranscriptionfactorsduringasymmetricdivisionestablishesfateofformingcancercells
AT douglascdean mitoticpolarizationoftranscriptionfactorsduringasymmetricdivisionestablishesfateofformingcancercells
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