Magnetization Reversal and Specific Loss Power of Magnetic Nanoparticles in Cellular Environment Evaluated by AC Hysteresis Measurement

The effect of intracellular hyperthermia induced by magnetic nanoparticles (MNPs) has been evaluated using a theoretical model. In this study, magnetization reversal of MNPs in the cellular environment under an AC magnetic field was evaluated on the basis of measured AC hysteresis loops. The specifi...

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Bibliographic Details
Main Authors: Satoshi Ota, Tsutomu Yamada, Yasushi Takemura
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Journal of Nanomaterials
Online Access:http://dx.doi.org/10.1155/2015/836761
Description
Summary:The effect of intracellular hyperthermia induced by magnetic nanoparticles (MNPs) has been evaluated using a theoretical model. In this study, magnetization reversal of MNPs in the cellular environment under an AC magnetic field was evaluated on the basis of measured AC hysteresis loops. The specific and intrinsic loss powers—SLP and ILP—were also estimated from the area of AC hysteresis loops. The measured samples were a liquid sample dispersed in water, a fixed sample mixed with an epoxy bond, and a cellular sample. In the cellular environment, the rotations of particles and magnetic moments were inhibited by particle-cell and dipole-dipole interactions, respectively. The heat dissipation of the MNPs in the cellular environment was lower than that of the liquid and fixed samples. Moreover, the SLP in a single cell was estimated. The temperature increase of a single cell was calculated on the basis of the conventional theoretical model and the SLP measured in a single cell.
ISSN:1687-4110
1687-4129