CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD.

CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD.

Age-related macular degeneration (AMD) is a prevalent cause of blindness in Western societies. Variants in the genes encoding complement factor H (CFH), complement component 3 (C3) and age-related maculopathy susceptibility 2 (ARMS2) have repeatedly been shown to confer significant risks for AMD; ho...

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Main Authors: Hendrik P N Scholl, Monika Fleckenstein, Lars G Fritsche, Steffen Schmitz-Valckenberg, Arno Göbel, Christine Adrion, Christine Herold, Claudia N Keilhauer, Friederike Mackensen, Andreas Mössner, Daniel Pauleikhoff, Andreas W A Weinberger, Ulrich Mansmann, Frank G Holz, Tim Becker, Bernhard H F Weber
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2756620?pdf=render

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