Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges

Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges

The research on natural snake venom metalloendopeptidase inhibitors (SVMPIs) began in the 18th century with the pioneering work of Fontana on the resistance that vipers exhibited to their own venom. During the past 40 years, SVMPIs have been isolated mainly from the sera of resistant animals, and ch...

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Bibliographic Details
Main Authors: Viviane A. Bastos, Francisco Gomes-Neto, Jonas Perales, Ana Gisele C. Neves-Ferreira, Richard H. Valente
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:Toxins
Subjects:
cross-linking
hydrogen/deuterium exchange
mass spectrometry
metalloendopeptidase inhibitor
modeling
natural immunity
natural resistance
snake venom
structure
therapeutic application
Online Access:http://www.mdpi.com/2072-6651/8/9/250

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http://www.mdpi.com/2072-6651/8/9/250

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