Emergence of Klebsiella pneumoniae-producing KPC-2 carbapenemase in Paraíba, Northeastern Brazil

Emergence of Klebsiella pneumoniae-producing KPC-2 carbapenemase in Paraíba, Northeastern Brazil

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The emergence of KPC-2 producing K. pneumoniae in hospitalized patients at the intensive care unit (ICU) of a teaching hospital located in the city of João Pessoa, Paraíba, Brazil, is reported. Seven carbapenem-resistant K. pneumoniae recovered from different body sites of infection were analyzed. M...

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Main Authors: Lorena C.C. Fehlberg, Albalucia M.C. Carvalho, Eloiza H. Campana, Paulo P. Gontijo-Filho, Ana C. Gales
Format: Article
Language:English
Published: Elsevier 2012-11-01
Series:Brazilian Journal of Infectious Diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S1413867012001924
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spelling doaj-df2cc64a035f4d3a8f029f18273d55672020-11-25T02:56:31ZengElsevierBrazilian Journal of Infectious Diseases1413-86702012-11-01166577580Emergence of Klebsiella pneumoniae-producing KPC-2 carbapenemase in Paraíba, Northeastern BrazilLorena C.C. Fehlberg0Albalucia M.C. Carvalho1Eloiza H. Campana2Paulo P. Gontijo-Filho3Ana C. Gales4Laboratório Alerta, Division of Infectious Diseases, Universidade Federal de São Paulo, São Paulo, SP, Brazil; Corresponding author at: Laboratório Alerta – Division of Infectious Diseases, Universidade Federal de São Paulo, Rua Leandro Dupret, 188, Vila Clementino – São Paulo/SP, 04025-010, Brazil.Hospital Universitário Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa, PB, BrazilLaboratório Alerta, Division of Infectious Diseases, Universidade Federal de São Paulo, São Paulo, SP, BrazilBiological Sciences Institute, Universidade Federal de Uberlândia, Uberlândia, MG, BrazilLaboratório Alerta, Division of Infectious Diseases, Universidade Federal de São Paulo, São Paulo, SP, BrazilThe emergence of KPC-2 producing K. pneumoniae in hospitalized patients at the intensive care unit (ICU) of a teaching hospital located in the city of João Pessoa, Paraíba, Brazil, is reported. Seven carbapenem-resistant K. pneumoniae recovered from different body sites of infection were analyzed. Most isolates showed a multidrug-resistance phenotype. Genotypic analysis demonstrated the presence of two genotypes, with the predominance of genotype A, which belongs to ST 437. These isolates also carry the encoding genes of five other beta-lactamases. Keywords: Beta-lactam resistance, Modified Hodge test, Carbapenem resistance, Enterobacteriaceaehttp://www.sciencedirect.com/science/article/pii/S1413867012001924
collection DOAJ
language English
format Article
sources DOAJ
author Lorena C.C. Fehlberg
Albalucia M.C. Carvalho
Eloiza H. Campana
Paulo P. Gontijo-Filho
Ana C. Gales
spellingShingle Lorena C.C. Fehlberg
Albalucia M.C. Carvalho
Eloiza H. Campana
Paulo P. Gontijo-Filho
Ana C. Gales
Emergence of Klebsiella pneumoniae-producing KPC-2 carbapenemase in Paraíba, Northeastern Brazil
Brazilian Journal of Infectious Diseases
author_facet Lorena C.C. Fehlberg
Albalucia M.C. Carvalho
Eloiza H. Campana
Paulo P. Gontijo-Filho
Ana C. Gales
author_sort Lorena C.C. Fehlberg
title Emergence of Klebsiella pneumoniae-producing KPC-2 carbapenemase in Paraíba, Northeastern Brazil
title_short Emergence of Klebsiella pneumoniae-producing KPC-2 carbapenemase in Paraíba, Northeastern Brazil
title_full Emergence of Klebsiella pneumoniae-producing KPC-2 carbapenemase in Paraíba, Northeastern Brazil
title_fullStr Emergence of Klebsiella pneumoniae-producing KPC-2 carbapenemase in Paraíba, Northeastern Brazil
title_full_unstemmed Emergence of Klebsiella pneumoniae-producing KPC-2 carbapenemase in Paraíba, Northeastern Brazil
title_sort emergence of klebsiella pneumoniae-producing kpc-2 carbapenemase in paraíba, northeastern brazil
publisher Elsevier
series Brazilian Journal of Infectious Diseases
issn 1413-8670
publishDate 2012-11-01
description The emergence of KPC-2 producing K. pneumoniae in hospitalized patients at the intensive care unit (ICU) of a teaching hospital located in the city of João Pessoa, Paraíba, Brazil, is reported. Seven carbapenem-resistant K. pneumoniae recovered from different body sites of infection were analyzed. Most isolates showed a multidrug-resistance phenotype. Genotypic analysis demonstrated the presence of two genotypes, with the predominance of genotype A, which belongs to ST 437. These isolates also carry the encoding genes of five other beta-lactamases. Keywords: Beta-lactam resistance, Modified Hodge test, Carbapenem resistance, Enterobacteriaceae
url http://www.sciencedirect.com/science/article/pii/S1413867012001924
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