A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity.

A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity.

Experimental and clinical evidence has pinpointed a critical role for matrix metalloproteinase-2 (MMP-2) in ischemic ventricular remodeling and systolic heart failure. Prior studies have demonstrated that transgenic expression of the full-length, 68 kDa, secreted form of MMP-2 induces severe systoli...

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Bibliographic Details
Main Authors: David H Lovett, Rajeev Mahimkar, Robert L Raffai, Leslie Cape, Elena Maklashina, Gary Cecchini, Joel S Karliner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3317925?pdf=render

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