Glycosylation of the hemagglutinin protein of H9N2 subtype avian influenza virus influences its replication and virulence in mice

Glycosylation of the hemagglutinin protein of H9N2 subtype avian influenza virus influences its replication and virulence in mice

N-Linked glycosylation of hemagglutinin (HA) has been demonstrated to regulate the virulence and receptor-binding specificity of avian influenza virus (AIV). In this study, we characterized the variation trend of naturally isolated H9N2 viruses for the potential N-linked glycosylation sites in HA pr...

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Bibliographic Details
Main Authors: Liu-gang TAN, Zhao-kun CHEN, Xin-xin MA, Qing-hua HUANG, Hai-ji SUN, Fan ZHANG, Shao-hua YANG, Chuan-tian XU, Ning CUI
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Journal of Integrative Agriculture
Subjects:
H9N2 AIV
hemagglutinin
N-linked glycosylation
receptor affinity
mice
Online Access:http://www.sciencedirect.com/science/article/pii/S2095311919626699

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