Granulocyte–colony stimulating factor plus plerixafor in patients with β-thalassemia major results in the effective mobilization of primitive CD34+ cells with specific gene expression profile

Granulocyte–colony stimulating factor plus plerixafor in patients with β-thalassemia major results in the effective mobilization of primitive CD34+ cells with specific gene expression profile

Successful gene therapy for β-thalassemia requires optimal numbers of autologous gene-transduced hematopoietic stem and progenitor cells (HSPCs) with high repopulating capacity. Previous studies suggested superior mobilization in these patients by the combination of granulocyte–colony stimulating fa...

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Bibliographic Details
Main Authors: Elena Baiamonte, Rita Barone, Flavia Contino, Rosalia Di Stefano, Anna Marfia, Aldo Filosa, Emanuela D'Angelo, Salvatore Feo, Santina Acuto, Aurelio Maggio
Format: Article
Language:English
Published: PAGEPress Publications 2017-05-01
Series:Thalassemia Reports
Subjects:
β-thalassemia
CD34+ cells expression profiling
G-CSF+plerixafor mobilization
gene therapy.
Online Access:http://www.pagepressjournals.org/index.php/thal/article/view/6392

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