BDNF Val66Met Genetic Polymorphism Results in Poor Recovery Following Repeated Mild Traumatic Brain Injury in a Mouse Model and Treatment With AAV-BDNF Improves Outcomes

BDNF Val66Met Genetic Polymorphism Results in Poor Recovery Following Repeated Mild Traumatic Brain Injury in a Mouse Model and Treatment With AAV-BDNF Improves Outcomes

Clinicians have long noticed that some Traumatic Brain Injury (TBI) patients have worse symptoms and take a longer time to recover than others, for reasons unexplained by known factors. Identifying what makes some individuals more susceptible is critical to understanding the underlying mechanisms th...

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Bibliographic Details
Main Authors: Anna O. Giarratana, Shavonne Teng, Sahithi Reddi, Cynthia Zheng, Derek Adler, Smita Thakker-Varia, Janet Alder
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Neurology
Subjects:
BDNF
lateral fluid percussion
Val66Met
rmTBI
AAV-BDNF
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.01175/full

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