Summary: | The chromen-4-one based vinyl ethers 3a–3e have been synthesized from the photochemical reaction of cyclobutylmethoxychromen-4-ones 2a–2e in dry MeOH. The compounds 2a–2e were easily obtained from the O-alkylation of different hydroxychromen-4-ones 1a–1e with bromomethyl-cyclobutane in the presence of anhydrous K2CO3/dry acetone and Bu4N+I− (PTC). The structure of the these compounds have been characterized from the rigorous analysis of their IR, 1H-NMR, 13C-NMR, ESI-MS and elemental analysis. The antibacterial and antifungal activities of newly prepared compounds were also evaluated against selected pathogens which include Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Pseudomonas florescens, Staphylococcus pyrogens, Klebsiella pneumoniae and Aspergillus janus, Aspergillus niger, Fusarium oxysporium, Aspergillus sclerotium, Penicillium glabrum respectively. Some of the studied compounds exhibited significant activity against the tested microorganisms.
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