Analysis of Fasting Urine pH as a Predictor of Insulin Resistance in Type 2 Diabetes Mellitus

• Main Authors: Arulmurugan C, Ranga Bashyam SR
• Format: Article
• Language: English
• Published: Amber Publication 2020-08-01
• Series: Journal of Research in Medical and Dental Science
• Subjects: diabetes; urine ph; homa ir; hba1c
• Online Access: https://www.jrmds.in/articles/analysis-of-fasting-urine-ph-as-a-predictor-of-insulin-resistance-in-type-2-diabetes-mellitus.pdf
• ISSN: 2347-2545; 2347-2367

Background and aim: Recent research articles suggest that a low urine pH related to more complications in type 2 diabetes mellitus. Our aim was to study of insulin resistance in type 2 diabetes patients using homeostasis model assessment and analysis of fasting urine pH as a predictor of insulin resistance in type 2 diabetes. Materials and methods: This prospective study was conducted in our hospital with type 2 diabetes mellitus patients during the period 2019 to 2020. A total of 102 patients have been taken for the study. Participants were isolated into two groups with urine pH <5.5 and the group with urine pH ≥ 5.5. We then further investigated the association between low urine pH levels and insulin resistance. Descriptive data were shown as the mean value of (Standard error) or number (%). The unpaired two sample t-test was used for analysis of continuous variables and the Chi-square test used for estimation of categorical variables. Results: Participants with urine pH <5.5 have high fasting blood glucose , HOMA IR index ,high triglycerides (P values <0.0001,P values <0.04, and P values <0.001 respectively) whereas patients with urine pH >5.5 have strong positive association with lower triglycerides levels and better glycemic control indicated by low HbA1C(P values <0.001,P values <0.0001 respectively). A significant inverse relationship was observed between urine pH levels and the extent of insulin resistance Conclusion: These observational findings concluded that fasting low urine pH can be used as simple, noninvasive, and easily available tool to estimate insulin resistance.