Proliferative glomerulonephritis associated with monoclonal immune deposits: A case report and review of literature

• Main Authors: R Fatima, R Jha, S Gowrishankar, G Narayen, B S Rao
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2014-01-01
• Series: Indian Journal of Nephrology
• Subjects: Monoclonal immune deposits; proliferative glomerulonephritis; immunofluorescence; outcome
• Online Access: http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2014;volume=24;issue=6;spage=376;epage=379;aulast=Fatima

Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) is a newly recognized entity caused by monoclonal deposition of IgG. PGNMID resembles immune complex glomerulonephritis (GN) on light and electron microscopy. The monotypic immunoglobulin deposits seen on immunofluorescence (IF) clinches the diagnosis. We report a case of proliferative GN associated MGRS and review the relevant literature. The patient had significant proteinuria and elevated serum creatinine. The renal biopsy showed proliferative GN with focal crescents and monoclonal immune deposits confirming a diagnosis of PGNMID. Serum work up showed no monoclonal proteins. Proliferative GN as a manifestation of a monoclonal gammopathy needs to be borne in mind especially in renal biopsies of older patients.