Proliferative glomerulonephritis associated with monoclonal immune deposits: A case report and review of literature

Proliferative glomerulonephritis associated with monoclonal immune deposits: A case report and review of literature

Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) is a newly recognized entity caused by monoclonal deposition of IgG. PGNMID resembles immune complex glomerulonephritis (GN) on light and electron microscopy. The monotypic immunoglobulin deposits seen on immunofluorescence (IF)...

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Bibliographic Details
Main Authors: R Fatima, R Jha, S Gowrishankar, G Narayen, B S Rao
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-01-01
Series:Indian Journal of Nephrology
Subjects:
Monoclonal immune deposits
proliferative glomerulonephritis
immunofluorescence
outcome
Online Access:http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2014;volume=24;issue=6;spage=376;epage=379;aulast=Fatima
Description
Summary:Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) is a newly recognized entity caused by monoclonal deposition of IgG. PGNMID resembles immune complex glomerulonephritis (GN) on light and electron microscopy. The monotypic immunoglobulin deposits seen on immunofluorescence (IF) clinches the diagnosis. We report a case of proliferative GN associated MGRS and review the relevant literature. The patient had significant proteinuria and elevated serum creatinine. The renal biopsy showed proliferative GN with focal crescents and monoclonal immune deposits confirming a diagnosis of PGNMID. Serum work up showed no monoclonal proteins. Proliferative GN as a manifestation of a monoclonal gammopathy needs to be borne in mind especially in renal biopsies of older patients.
ISSN:0971-4065
1998-3662

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