The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction
The molecular pathways regulating the cardioprotective activity of deacetylase sirtuin-1 are unknown. Here, Yanget al. show that histone H3K9 methyltransferase SUV39H and HP1gamma cooperatively methylate H3K9 on the sirtuin-1 promoter and inhibit sirtuin-1 transcription, and show that inhibition of...
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Bibliographic Details
| Main Authors: |
Guang Yang,
Xinyu Weng,
Yuhao Zhao,
Xinjian Zhang,
Yuanping Hu,
Xin Dai,
Peng Liang,
Peng Wang,
LeiLei Ma,
Xiaolei Sun,
Lei Hou,
Huihui Xu,
Mingming Fang,
Yuehua Li,
Thomas Jenuwein,
Yong Xu,
Aijun Sun |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms14941
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