Absence of PKC-alpha attenuates lithium-induced nephrogenic diabetes insipidus.

Absence of PKC-alpha attenuates lithium-induced nephrogenic diabetes insipidus.

Lithium, an effective antipsychotic, induces nephrogenic diabetes insipidus (NDI) in ∼40% of patients. The decreased capacity to concentrate urine is likely due to lithium acutely disrupting the cAMP pathway and chronically reducing urea transporter (UT-A1) and water channel (AQP2) expression in the...

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Bibliographic Details
Main Authors: Jae H Sim, Nathaniel J Himmel, Sara K Redd, Fadi E Pulous, Richard T Rogers, Lauren N Black, Seongun M Hong, Tobias N von Bergen, Mitsi A Blount
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4090211?pdf=render

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