Antifungal activity of fused Mannich ketones triggers an oxidative stress response and is Cap1-dependent in Candida albicans.

Antifungal activity of fused Mannich ketones triggers an oxidative stress response and is Cap1-dependent in Candida albicans.

We investigated the antifungal activity of fused Mannich ketone (FMK) congeners and two of their aminoalcohol derivatives. In particular, FMKs with five-membered saturated rings were shown to have minimum inhibitory concentration (MIC90s) ranging from 0.8 to 6 µg/mL toward C. albicans and the closel...

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Main Authors: Tristan Rossignol, Béla Kocsis, Orsolya Bouquet, Ildikó Kustos, Ferenc Kilár, Adrien Nyul, Péter B Jakus, Kshitij Rajbhandari, László Prókai, Christophe d'Enfert, Tamás Lóránd
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23646117/?tool=EBI

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