Effects of proton pump inhibitors on reversing multidrug resistance via downregulating V-ATPases/PI3K/Akt/mTOR/HIF-1α signaling pathway through TSC1/2 complex and Rheb in human gastric adenocarcinoma cells in vitro and in vivo

Effects of proton pump inhibitors on reversing multidrug resistance via downregulating V-ATPases/PI3K/Akt/mTOR/HIF-1α signaling pathway through TSC1/2 complex and Rheb in human gastric adenocarcinoma cells in vitro and in vivo

Min Chen,1,* Jian Lu,1–3,* Wei Wei,4,* Ying Lv,1 Xiaoqi Zhang,1 Yuling Yao,1 Lei Wang,1 Tingsheng Ling,1,5 Xiaoping Zou1 1Department of Gastroenterology the Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing 210008, People’s Republic of China; 2Departm...

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Bibliographic Details
Main Authors: Chen M, Lu J, Wei W, Lv Y, Zhang X, Yao Y, Wang L, Ling T, Zou X
Format: Article
Language:English
Published: Dove Medical Press 2018-10-01
Series:OncoTargets and Therapy
Subjects:
Gastric cancer
Vacuolar H+-ATPases
Tumor acidity
Hypoxia
Proton pump inhibitors
Online Access:https://www.dovepress.com/effects-of-proton-pump-inhibitors-on-reversing-multidrug-resistance-vi-peer-reviewed-article-OTT

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