Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells
Prohibitin 2 can localize to the axon-Schwann-cell interface and is required for myelin formation. Here, the authors show that deletion of prohibitin 1 in Schwann cells instead triggers severe myelin loss likely caused by mitochondrial dysfunction, and not rescued by inhibition of the ensuing integr...
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Bibliographic Details
| Main Authors: |
Gustavo Della-Flora Nunes,
Emma R. Wilson,
Leandro N. Marziali,
Edward Hurley,
Nicholas Silvestri,
Bin He,
Bert W. O’Malley,
Bogdan Beirowski,
Yannick Poitelon,
Lawrence Wrabetz,
M. Laura Feltri |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-23552-8
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