Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells

Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells

Prohibitin 2 can localize to the axon-Schwann-cell interface and is required for myelin formation. Here, the authors show that deletion of prohibitin 1 in Schwann cells instead triggers severe myelin loss likely caused by mitochondrial dysfunction, and not rescued by inhibition of the ensuing integr...

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Bibliographic Details
Main Authors: Gustavo Della-Flora Nunes, Emma R. Wilson, Leandro N. Marziali, Edward Hurley, Nicholas Silvestri, Bin He, Bert W. O’Malley, Bogdan Beirowski, Yannick Poitelon, Lawrence Wrabetz, M. Laura Feltri
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23552-8

Internet

https://doi.org/10.1038/s41467-021-23552-8

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