What Do We Need beyond Hemoglobin A1c to Get the Complete Picture of Glycemia in People with Diabetes?
<p>Hemoglobin A1c (HbA1c) is currently the most commonly used marker for the determination of the glycemic status in people with diabetes and it is frequently used to guide therapy and especially medical treatment of people with diabetes. The measurement of HbA1c has reached a high level of an...
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doaj-dec5e6ef6e784009ac7fcd73c92b96402020-11-24T21:12:53ZengIvyspring International PublisherInternational Journal of Medical Sciences1449-19072012-01-0198665681What Do We Need beyond Hemoglobin A1c to Get the Complete Picture of Glycemia in People with Diabetes?Rolf Hinzmann, Christof Schlaeger, Cam Tuan Tran<p>Hemoglobin A1c (HbA1c) is currently the most commonly used marker for the determination of the glycemic status in people with diabetes and it is frequently used to guide therapy and especially medical treatment of people with diabetes. The measurement of HbA1c has reached a high level of analytical quality and, therefore, this biomarker is currently also suggested to be used for the diagnosis of diabetes. Nevertheless, it is crucial for people with diabetes and their treating physicians to be aware of possible interferences during its measurement as well as physiological or pathological factors that contribute to the HbA1c concentration without being related to glycemia, which are discussed in this review. We performed a comprehensive review of the literature based on PubMed searches on HbA1c in the treatment and diagnosis of diabetes including its most relevant limitations, glycemic variability and self-monitoring of blood glucose (SMBG). Although the high analytical quality of the HbA1c test is widely acknowledged, the clinical relevance of this marker regarding risk reduction of cardiovascular morbidity and mortality is still under debate. In this respect, we argue that glycemic variability as a further risk factor should deserve more attention in the treatment of diabetes.</p>http://www.medsci.org/v09p0665.htm |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rolf Hinzmann, Christof Schlaeger, Cam Tuan Tran |
spellingShingle |
Rolf Hinzmann, Christof Schlaeger, Cam Tuan Tran What Do We Need beyond Hemoglobin A1c to Get the Complete Picture of Glycemia in People with Diabetes? International Journal of Medical Sciences |
author_facet |
Rolf Hinzmann, Christof Schlaeger, Cam Tuan Tran |
author_sort |
Rolf Hinzmann, Christof Schlaeger, Cam Tuan Tran |
title |
What Do We Need beyond Hemoglobin A1c to Get the Complete Picture of Glycemia in People with Diabetes? |
title_short |
What Do We Need beyond Hemoglobin A1c to Get the Complete Picture of Glycemia in People with Diabetes? |
title_full |
What Do We Need beyond Hemoglobin A1c to Get the Complete Picture of Glycemia in People with Diabetes? |
title_fullStr |
What Do We Need beyond Hemoglobin A1c to Get the Complete Picture of Glycemia in People with Diabetes? |
title_full_unstemmed |
What Do We Need beyond Hemoglobin A1c to Get the Complete Picture of Glycemia in People with Diabetes? |
title_sort |
what do we need beyond hemoglobin a1c to get the complete picture of glycemia in people with diabetes? |
publisher |
Ivyspring International Publisher |
series |
International Journal of Medical Sciences |
issn |
1449-1907 |
publishDate |
2012-01-01 |
description |
<p>Hemoglobin A1c (HbA1c) is currently the most commonly used marker for the determination of the glycemic status in people with diabetes and it is frequently used to guide therapy and especially medical treatment of people with diabetes. The measurement of HbA1c has reached a high level of analytical quality and, therefore, this biomarker is currently also suggested to be used for the diagnosis of diabetes. Nevertheless, it is crucial for people with diabetes and their treating physicians to be aware of possible interferences during its measurement as well as physiological or pathological factors that contribute to the HbA1c concentration without being related to glycemia, which are discussed in this review. We performed a comprehensive review of the literature based on PubMed searches on HbA1c in the treatment and diagnosis of diabetes including its most relevant limitations, glycemic variability and self-monitoring of blood glucose (SMBG). Although the high analytical quality of the HbA1c test is widely acknowledged, the clinical relevance of this marker regarding risk reduction of cardiovascular morbidity and mortality is still under debate. In this respect, we argue that glycemic variability as a further risk factor should deserve more attention in the treatment of diabetes.</p> |
url |
http://www.medsci.org/v09p0665.htm |
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