Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation

Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation

Caterina Iorio et al. use a high-throughput RNAi screen to identify the GPR3-SIK2-CDKN1B axis as key players involved in regulating pancreatic beta cell proliferation. These results suggest that GPR3 and SIK2 are both potential targets to stimulate regeneration of beta cells in diseases like type 1...

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Main Authors: Caterina Iorio, Jillian L. Rourke, Lisa Wells, Jun-Ichi Sakamaki, Emily Moon, Queenie Hu, Tatsuya Kin, Robert A. Screaton
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02433-2
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spelling doaj-dec25cc1168a4f9bbbd67253be0024832021-07-25T11:11:28ZengNature Publishing GroupCommunications Biology2399-36422021-07-014111310.1038/s42003-021-02433-2Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferationCaterina Iorio0Jillian L. Rourke1Lisa Wells2Jun-Ichi Sakamaki3Emily Moon4Queenie Hu5Tatsuya Kin6Robert A. Screaton7Sunnybrook Research InstituteSunnybrook Research InstituteSunnybrook Research InstituteDepartment of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of TokyoSunnybrook Research InstituteSunnybrook Research InstituteClinical Islet Laboratory, University of Alberta HospitalSunnybrook Research InstituteCaterina Iorio et al. use a high-throughput RNAi screen to identify the GPR3-SIK2-CDKN1B axis as key players involved in regulating pancreatic beta cell proliferation. These results suggest that GPR3 and SIK2 are both potential targets to stimulate regeneration of beta cells in diseases like type 1 diabetes.https://doi.org/10.1038/s42003-021-02433-2
collection DOAJ
language English
format Article
sources DOAJ
author Caterina Iorio
Jillian L. Rourke
Lisa Wells
Jun-Ichi Sakamaki
Emily Moon
Queenie Hu
Tatsuya Kin
Robert A. Screaton
spellingShingle Caterina Iorio
Jillian L. Rourke
Lisa Wells
Jun-Ichi Sakamaki
Emily Moon
Queenie Hu
Tatsuya Kin
Robert A. Screaton
Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation
Communications Biology
author_facet Caterina Iorio
Jillian L. Rourke
Lisa Wells
Jun-Ichi Sakamaki
Emily Moon
Queenie Hu
Tatsuya Kin
Robert A. Screaton
author_sort Caterina Iorio
title Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation
title_short Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation
title_full Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation
title_fullStr Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation
title_full_unstemmed Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation
title_sort silencing the g-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-07-01
description Caterina Iorio et al. use a high-throughput RNAi screen to identify the GPR3-SIK2-CDKN1B axis as key players involved in regulating pancreatic beta cell proliferation. These results suggest that GPR3 and SIK2 are both potential targets to stimulate regeneration of beta cells in diseases like type 1 diabetes.
url https://doi.org/10.1038/s42003-021-02433-2
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AT lisawells silencingthegproteincoupledreceptor3saltinduciblekinase2pathwaypromoteshumanbcellproliferation
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