Role of PFKFB3 and PFKFB4 in Cancer: Genetic Basis, Impact on Disease Development/Progression, and Potential as Therapeutic Targets

Role of PFKFB3 and PFKFB4 in Cancer: Genetic Basis, Impact on Disease Development/Progression, and Potential as Therapeutic Targets

Glycolysis is a crucial metabolic process in rapidly proliferating cells such as cancer cells. Phosphofructokinase-1 (PFK-1) is a key rate-limiting enzyme of glycolysis. Its efficiency is allosterically regulated by numerous substances occurring in the cytoplasm. However, the most potent regulator o...

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Bibliographic Details
Main Authors:	Krzysztof Kotowski, Jakub Rosik, Filip Machaj, Stanisław Supplitt, Daniel Wiczew, Karolina Jabłońska, Emilia Wiechec, Saeid Ghavami, Piotr Dzięgiel
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Series:	Cancers
Subjects:	PFKFB3 PFKFB4 PFK-2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3PO PFK-158
Online Access:	https://www.mdpi.com/2072-6694/13/4/909

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