Tyrosine Kinase Inhibitor Resistance in Patients with Chronic Myeloid Leukemia: A 10-Year Study of BCR-ABL Gene Mutation Profile in Russia (2006–2016)

Tyrosine Kinase Inhibitor Resistance in Patients with Chronic Myeloid Leukemia: A 10-Year Study of BCR-ABL Gene Mutation Profile in Russia (2006–2016)

Background. Kinase domain mutations of BCR-ABL gene is the most common cause of tyrosine kinase inhibitor resistance. Aim. To present the data on prognostic value of BCR-ABL mutation burden in Russian patients over the last 10 years. Materials & Methods. The study included 1885 chronic mye...

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Bibliographic Details
Main Authors: VV Tikhonova, MA Isakov, VA Misyurin, YuP Finashutina, LA Kesaeva, NA Lyzhko, IN Soldatova, NN Kasatkina, EN Misyurina, AV Misyurin
Format: Article
Language:Russian
Published: Practical Medicine Publishing House 2018-07-01
Series:Kliničeskaâ onkogematologiâ
Subjects:
chronic myeloid leukemia
kinase domain mutations of BCR-ABL gene
targeted therapy
resistance
Online Access:http://bloodjournal.ru/wp-content/uploads/2018/06/3-2.pdf

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