Kinetic Isotope Effect of Prostaglandin H Synthase Exhibits Inverted Temperature Dependence
Conversion of arachidonic acid to prostaglandin G2/H2 catalyzed by prostaglandin H synthase (PGHS) is proposed to involve initial transfer of the C13 pro-(S) hydrogen atom from arachidonate to the Tyr385 radical in PGHS, followed by insertion of two oxygen molecules and several chemical bond rearran...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2014-06-01
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| Series: | Catalysts |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2073-4344/4/2/174 |