Multi-Stability and Consequent Phenotypic Plasticity in AMPK-Akt Double Negative Feedback Loop in Cancer Cells

Multi-Stability and Consequent Phenotypic Plasticity in AMPK-Akt Double Negative Feedback Loop in Cancer Cells

Adaptation and survival of cancer cells to various stress and growth factor conditions is crucial for successful metastasis. A double-negative feedback loop between two serine/threonine kinases AMPK (AMP-activated protein kinase) and Akt can regulate the adaptation of breast cancer cells to matrix-d...

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Bibliographic Details
Main Authors: Adithya Chedere, Kishore Hari, Saurav Kumar, Annapoorni Rangarajan, Mohit Kumar Jolly
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Journal of Clinical Medicine
Subjects:
phenotypic plasticity
bistability
double negative feedback loop
AMPK
Akt
matrix deprivation
Online Access:https://www.mdpi.com/2077-0383/10/3/472

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