A Review of the Synthetic Strategies toward Dihydropyrrolo[1,2-<em>a</em>]Pyrazinones

Dihydropyrrolo[1,2-<i>a</i>]pyrazinone rings are a class of heterocycles present in a wide range of bioactive natural products and analogues thereof. As a direct result of their bioactivity, the synthesis of this privileged class of compounds has been extensively studied. This review pro...

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Main Authors:	Pieterjan Winant, Tomas Horsten, Shaiani Maria Gil de Melo, Flavio Emery, Wim Dehaen
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Series:	Organics
Subjects:	pyrrole pyrazinone heterocycle natural product cycloaddition multicomponent reaction
Online Access:	https://www.mdpi.com/2673-401X/2/2/11

id	doaj-deb4e6adae474dd4a017c6ba960015a3
record_format	Article
spelling	doaj-deb4e6adae474dd4a017c6ba960015a32021-07-15T15:43:15ZengMDPI AGOrganics2673-401X2021-06-0121111814110.3390/org2020011A Review of the Synthetic Strategies toward Dihydropyrrolo[1,2-<em>a</em>]PyrazinonesPieterjan Winant0Tomas Horsten1Shaiani Maria Gil de Melo2Flavio Emery3Wim Dehaen4Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, BelgiumMolecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, BelgiumDepartment of Pharmaceutical Sciences, School of Pharmaceutical Sciences at Ribeirao Preto of the University of Sao Paulo, Ribeirao Preto 14040903, SP, BrazilDepartment of Pharmaceutical Sciences, School of Pharmaceutical Sciences at Ribeirao Preto of the University of Sao Paulo, Ribeirao Preto 14040903, SP, BrazilMolecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, BelgiumDihydropyrrolo[1,2-<i>a</i>]pyrazinone rings are a class of heterocycles present in a wide range of bioactive natural products and analogues thereof. As a direct result of their bioactivity, the synthesis of this privileged class of compounds has been extensively studied. This review provides an overview of these synthetic pathways. The literature is covered up until 2020 and is organized according to the specific strategies used to construct the scaffold: fusing a pyrazinone to an existing pyrrole, employing a pyrazinone-first strategy, an array of multicomponent reactions and some miscellaneous reactions.https://www.mdpi.com/2673-401X/2/2/11pyrrolepyrazinoneheterocyclenatural productcycloadditionmulticomponent reaction
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Pieterjan Winant Tomas Horsten Shaiani Maria Gil de Melo Flavio Emery Wim Dehaen
spellingShingle	Pieterjan Winant Tomas Horsten Shaiani Maria Gil de Melo Flavio Emery Wim Dehaen A Review of the Synthetic Strategies toward Dihydropyrrolo[1,2-<em>a</em>]Pyrazinones Organics pyrrole pyrazinone heterocycle natural product cycloaddition multicomponent reaction
author_facet	Pieterjan Winant Tomas Horsten Shaiani Maria Gil de Melo Flavio Emery Wim Dehaen
author_sort	Pieterjan Winant
title	A Review of the Synthetic Strategies toward Dihydropyrrolo[1,2-<em>a</em>]Pyrazinones
title_short	A Review of the Synthetic Strategies toward Dihydropyrrolo[1,2-<em>a</em>]Pyrazinones
title_full	A Review of the Synthetic Strategies toward Dihydropyrrolo[1,2-<em>a</em>]Pyrazinones
title_fullStr	A Review of the Synthetic Strategies toward Dihydropyrrolo[1,2-<em>a</em>]Pyrazinones
title_full_unstemmed	A Review of the Synthetic Strategies toward Dihydropyrrolo[1,2-<em>a</em>]Pyrazinones
title_sort	review of the synthetic strategies toward dihydropyrrolo[1,2-<em>a</em>]pyrazinones
publisher	MDPI AG
series	Organics
issn	2673-401X
publishDate	2021-06-01
description	Dihydropyrrolo[1,2-<i>a</i>]pyrazinone rings are a class of heterocycles present in a wide range of bioactive natural products and analogues thereof. As a direct result of their bioactivity, the synthesis of this privileged class of compounds has been extensively studied. This review provides an overview of these synthetic pathways. The literature is covered up until 2020 and is organized according to the specific strategies used to construct the scaffold: fusing a pyrazinone to an existing pyrrole, employing a pyrazinone-first strategy, an array of multicomponent reactions and some miscellaneous reactions.
topic	pyrrole pyrazinone heterocycle natural product cycloaddition multicomponent reaction
url	https://www.mdpi.com/2673-401X/2/2/11
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A Review of the Synthetic Strategies toward Dihydropyrrolo[1,2-<em>a</em>]Pyrazinones

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