Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans.

Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans.

Mycolactones, macrolide cytotoxins, are key virulence factors of Mycobacterium ulcerans, the etiological agent of the chronic necrotizing skin disease Buruli ulcer. There is urgent need for a simple point-of-care laboratory test for Buruli ulcer and mycolactone represents a promising target for the...

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Bibliographic Details
Main Authors: Louisa Warryn, Jean-Pierre Dangy, Philipp Gersbach, Matthias Gehringer, Anja Schäfer, Marie-Thérèse Ruf, Nicolas Ruggli, Karl-Heinz Altmann, Gerd Pluschke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-06-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0008357

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