Effects of Piperazine Derivative on Paclitaxel Pharmacokinetics

Effects of Piperazine Derivative on Paclitaxel Pharmacokinetics

Paclitaxel (PTX) is an anticancer agent that is used to treat many cancers but it has a very low oral bioavailability due, at least in part, to the drug efflux transporter, P-glycoprotein (P-gp). Therefore, this study was performed to enhance oral bioavailability of PTX. In this study, we investigat...

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Bibliographic Details
Main Authors: Jaeok Lee, Song Wha Chae, A Reum Oh, Ji Hye Yoo, Hea-Young Park Choo, Sandy Jeong Rhie, Hwa Jeong Lee
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Pharmaceutics
Subjects:
piperazine derivatives
P-glycoprotein inhibitor
pharmacokinetics
bioavailability
paclitaxel
Online Access:http://www.mdpi.com/1999-4923/11/1/23

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