Microparticles mediate hepatic ischemia-reperfusion injury and are the targets of Diannexin (ASP8597).

Microparticles mediate hepatic ischemia-reperfusion injury and are the targets of Diannexin (ASP8597).

BACKGROUND & AIMS: Ischemia-reperfusion injury (IRI) can cause hepatic failure after liver surgery or transplantation. IRI causes oxidative stress, which injures sinusoidal endothelial cells (SECs), leading to recruitment and activation of Kupffer cells, platelets and microcirculatory impairment...

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Bibliographic Details
Main Authors: Narci C Teoh, Hussam Ajamieh, Heng Jian Wong, Kevin Croft, Trevor Mori, Anthony C Allison, Geoffrey C Farrell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4164362?pdf=render

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