Altered Jagged1-Notch1 Signaling in Enhanced Dysfunctional Neovascularization and Delayed Angiogenesis After Ischemic Stroke in HFD/STZ Induced Type 2 Diabetes Rats

Altered Jagged1-Notch1 Signaling in Enhanced Dysfunctional Neovascularization and Delayed Angiogenesis After Ischemic Stroke in HFD/STZ Induced Type 2 Diabetes Rats

Diabetes exacerbates brain damage in cerebral ischemic stroke. Our previous study has demonstrated that after cerebral ischemia, type 2 diabetes rats displayed worse neurological outcomes, larger cerebral infarction and severer blood-brain barrier disruption. However, our knowledge of the mechanisms...

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Bibliographic Details
Main Authors: Zhihui Guo, Jia Jia, Yanling Tu, Chang Jin, Cen Guo, Feifei Song, Xuqing Wu, Haifeng Bao, Wei Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Physiology
Subjects:
Jagged1
Notch1
neovascularization
angiogenesis
cerebral ischemia
T2DM
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.687947/full

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