Natural HDAC‐1/8 inhibitor baicalein exerts therapeutic effect in CBF‐AML

Natural HDAC‐1/8 inhibitor baicalein exerts therapeutic effect in CBF‐AML

Abstract Background Although targeting histone deacetylases (HDACs) may be an effective strategy for core binding factor‐acute myeloid leukemia (CBF‐AML) harboring t(8;21) or inv(16), HDAC inhibitors are reported to be limited by drug‐resistant characteristic. Our purpose is to evaluate the anti‐leu...

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Bibliographic Details
Main Authors: Xiaoxuan Yu, Hui Li, Po Hu, Yingjie Qing, Xiangyuan Wang, Mengyuan Zhu, Hongzheng Wang, Zhanyu Wang, Jingyan Xu, Qinglong Guo, Hui Hui
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Clinical and Translational Medicine
Subjects:
ABC transporter genes
CBF‐AML
differentiation
HDAC‐1/8 inhibitors
natural product
Online Access:https://doi.org/10.1002/ctm2.154

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