Upper digestive tract abnormalities in dogs with chronic idiopathic lymphoplasmacytic rhinitis

Abstract Background Chronic idiopathic lymphoplasmacytic rhinitis (CILPR) is a common inflammatory disorder of unknown etiology affecting the nasal cavity of dogs. The diagnosis is made by exclusion of other causes of nasal disease and specific therapeutic protocols are lacking. In human medicine, a...

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Main Authors: Paola Gianella, Silvia Roncone, Ugo Ala, Enrico Bottero, Federica Cagnasso, Giulia Cagnotti, Claudio Bellino
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Journal of Veterinary Internal Medicine
Subjects:
Online Access:https://doi.org/10.1111/jvim.15827
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spelling doaj-de7ea460be204a35a56121eab00c988a2020-11-25T03:41:50ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762020-09-013451845185210.1111/jvim.15827Upper digestive tract abnormalities in dogs with chronic idiopathic lymphoplasmacytic rhinitisPaola Gianella0Silvia Roncone1Ugo Ala2Enrico Bottero3Federica Cagnasso4Giulia Cagnotti5Claudio Bellino6Department of Veterinary Science University of Turin Grugliasco ItalyDepartment of Veterinary Science University of Turin Grugliasco ItalyDepartment of Veterinary Science University of Turin Grugliasco ItalyPoliambulatorio Veterinario Argentina Imperia ItalyDepartment of Veterinary Science University of Turin Grugliasco ItalyDepartment of Veterinary Science University of Turin Grugliasco ItalyDepartment of Veterinary Science University of Turin Grugliasco ItalyAbstract Background Chronic idiopathic lymphoplasmacytic rhinitis (CILPR) is a common inflammatory disorder of unknown etiology affecting the nasal cavity of dogs. The diagnosis is made by exclusion of other causes of nasal disease and specific therapeutic protocols are lacking. In human medicine, a relationship between CILPR and gastrointestinal clinical signs has been postulated, and remission of respiratory signs after clinical trials with medications for gastrointestinal disorders has been observed. Objectives To describe history, clinical presentation, endoscopic and histopathologic concurrent respiratory and digestive tract abnormalities, and to evaluate improvement of respiratory signs after treatment for gastrointestinal signs. Animals Twenty‐five dogs with CILPR. Methods Prospective study. For inclusion, following information had to be available: respiratory and digestive clinical signs, airway and digestive tract endoscopic abnormalities, histologic evaluation of respiratory and gastrointestinal tract biopsy specimens, and clinical response to different treatment strategies. Results Twenty‐two dogs had endoscopic gastrointestinal lesions, whereas 13 dogs had concurrent gastrointestinal signs. Most esophageal and duodenal endoscopic abnormalities were classified as moderate or severe. Respiratory and gastrointestinal tract histologic evaluation identified mostly chronic inflammation. Remission or marked improvement of respiratory signs was observed in the majority of dogs treated only for gastrointestinal signs up to 12 months after endoscopy. No significant associations between treatments and follow‐up information were found. Conclusion and Clinical Importance Nasal and upper digestive tract abnormalities coexist in some dogs with CILPR. Lack of standardized therapeutic protocols suggests caution when interpreting improvement in nasal clinical signs. Additional studies are needed to explore the possibility of a cause‐effect relationship between the 2 processes.https://doi.org/10.1111/jvim.15827clinical signsendoscopyfollow‐uptreatmentvomiting
collection DOAJ
language English
format Article
sources DOAJ
author Paola Gianella
Silvia Roncone
Ugo Ala
Enrico Bottero
Federica Cagnasso
Giulia Cagnotti
Claudio Bellino
spellingShingle Paola Gianella
Silvia Roncone
Ugo Ala
Enrico Bottero
Federica Cagnasso
Giulia Cagnotti
Claudio Bellino
Upper digestive tract abnormalities in dogs with chronic idiopathic lymphoplasmacytic rhinitis
Journal of Veterinary Internal Medicine
clinical signs
endoscopy
follow‐up
treatment
vomiting
author_facet Paola Gianella
Silvia Roncone
Ugo Ala
Enrico Bottero
Federica Cagnasso
Giulia Cagnotti
Claudio Bellino
author_sort Paola Gianella
title Upper digestive tract abnormalities in dogs with chronic idiopathic lymphoplasmacytic rhinitis
title_short Upper digestive tract abnormalities in dogs with chronic idiopathic lymphoplasmacytic rhinitis
title_full Upper digestive tract abnormalities in dogs with chronic idiopathic lymphoplasmacytic rhinitis
title_fullStr Upper digestive tract abnormalities in dogs with chronic idiopathic lymphoplasmacytic rhinitis
title_full_unstemmed Upper digestive tract abnormalities in dogs with chronic idiopathic lymphoplasmacytic rhinitis
title_sort upper digestive tract abnormalities in dogs with chronic idiopathic lymphoplasmacytic rhinitis
publisher Wiley
series Journal of Veterinary Internal Medicine
issn 0891-6640
1939-1676
publishDate 2020-09-01
description Abstract Background Chronic idiopathic lymphoplasmacytic rhinitis (CILPR) is a common inflammatory disorder of unknown etiology affecting the nasal cavity of dogs. The diagnosis is made by exclusion of other causes of nasal disease and specific therapeutic protocols are lacking. In human medicine, a relationship between CILPR and gastrointestinal clinical signs has been postulated, and remission of respiratory signs after clinical trials with medications for gastrointestinal disorders has been observed. Objectives To describe history, clinical presentation, endoscopic and histopathologic concurrent respiratory and digestive tract abnormalities, and to evaluate improvement of respiratory signs after treatment for gastrointestinal signs. Animals Twenty‐five dogs with CILPR. Methods Prospective study. For inclusion, following information had to be available: respiratory and digestive clinical signs, airway and digestive tract endoscopic abnormalities, histologic evaluation of respiratory and gastrointestinal tract biopsy specimens, and clinical response to different treatment strategies. Results Twenty‐two dogs had endoscopic gastrointestinal lesions, whereas 13 dogs had concurrent gastrointestinal signs. Most esophageal and duodenal endoscopic abnormalities were classified as moderate or severe. Respiratory and gastrointestinal tract histologic evaluation identified mostly chronic inflammation. Remission or marked improvement of respiratory signs was observed in the majority of dogs treated only for gastrointestinal signs up to 12 months after endoscopy. No significant associations between treatments and follow‐up information were found. Conclusion and Clinical Importance Nasal and upper digestive tract abnormalities coexist in some dogs with CILPR. Lack of standardized therapeutic protocols suggests caution when interpreting improvement in nasal clinical signs. Additional studies are needed to explore the possibility of a cause‐effect relationship between the 2 processes.
topic clinical signs
endoscopy
follow‐up
treatment
vomiting
url https://doi.org/10.1111/jvim.15827
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