Hypoxia Supports Epicardial Cell Differentiation in Vascular Smooth Muscle Cells through the Activation of the TGFβ Pathway

Hypoxia Supports Epicardial Cell Differentiation in Vascular Smooth Muscle Cells through the Activation of the TGFβ Pathway

Epicardium-derived cells (EPDCs) are an important pool of multipotent cardiovascular progenitor cells. Through epithelial-to-mesenchymal-transition (EMT), EPDCs invade the subepicardium and myocardium and further differentiate into several cell types required for coronary vessel formation. We previo...

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Bibliographic Details
Main Authors:	Jiayi Tao, Joey V. Barnett, Michiko Watanabe, Diana Ramírez-Bergeron
Format:	Article
Language:	English
Published:	MDPI AG 2018-04-01
Series:	Journal of Cardiovascular Development and Disease
Subjects:	hypoxia inducible factor hypoxia transforming growth factor beta TGFβ RhoA/ROCK epicardial cell epithelial-to-mesenchymal-transition vascular smooth muscle cells coronary vasculature
Online Access:	http://www.mdpi.com/2308-3425/5/2/19

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