Bile alcohols function as the ligands of membrane-type bile acid-activated G protein-coupled receptor

Bile alcohols function as the ligands of membrane-type bile acid-activated G protein-coupled receptor

TGR5 is a G protein-coupled receptor that is activated by bile acids, resulting in an increase in cAMP levels and the subsequent modulation of energy expenditure in brown adipose tissue and muscle. Therefore, the development of a TGR5-specific agonist could lead to the prevention and treatment of va...

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Bibliographic Details
Main Authors: Yusuke Iguchi, Masafumi Yamaguchi, Hiroyuki Sato, Kenji Kihira, Tomoko Nishimaki-Mogami, Mizuho Une
Format: Article
Language:English
Published: Elsevier 2010-06-01
Series:Journal of Lipid Research
Subjects:
TGR5
structure-activity relationship
FXR
drug development
metabolic syndrome
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752041017X

Internet

http://www.sciencedirect.com/science/article/pii/S002222752041017X

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