Oncogene addiction and radiation oncology: effect of radiotherapy with photons and carbon ions in ALK-EML4 translocated NSCLC

Oncogene addiction and radiation oncology: effect of radiotherapy with photons and carbon ions in ALK-EML4 translocated NSCLC

Abstract Background Patients with Echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) positive lung cancer are sensitive to ALK-kinase inhibitors. TAE684 is a potent second generation ALK inhibitor that overcomes Crizotinib resistance. Radiotherapy is an integral...

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Bibliographic Details
Main Authors: Ying Dai, Quanxiang Wei, Christian Schwager, Janina Hanne, Cheng Zhou, Klaus Herfarth, Stefan Rieken, Kenneth E. Lipson, Jürgen Debus, Amir Abdollahi
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Radiation Oncology
Subjects:
Non-small-cell lung cancer
EML4-ALK-fusion
ALK inhibitors
Radiotherapy
Carbon ions
Online Access:http://link.springer.com/article/10.1186/s13014-017-0947-0

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