Comparative Evaluation of MS-based Metabolomics Software and Its Application to Preclinical Alzheimer’s Disease

Comparative Evaluation of MS-based Metabolomics Software and Its Application to Preclinical Alzheimer’s Disease

Abstract Mass spectrometry-based metabolomics has undergone significant progresses in the past decade, with a variety of software packages being developed for data analysis. However, systematic comparison of different metabolomics software tools has rarely been conducted. In this study, several repr...

Full description

Bibliographic Details
Main Authors:	Ling Hao, Jingxin Wang, David Page, Sanjay Asthana, Henrik Zetterberg, Cynthia Carlsson, Ozioma C. Okonkwo, Lingjun Li
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-06-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-018-27031-x

Similar Items

A Strategy for Discovery and Verification of Candidate Biomarkers in Cerebrospinal Fluid of Preclinical Alzheimer’s Disease
by: Xiaofang Zhong, et al.
Published: (2019-01-01)

Microstructural white matter alterations in preclinical Alzheimer's disease detected using free water elimination diffusion tensor imaging.
by: Andrew R Hoy, et al.
Published: (2017-01-01)

Associations between white matter microstructure and amyloid burden in preclinical Alzheimer's disease: A multimodal imaging investigation
by: Annie M. Racine, et al.
Published: (2014-01-01)

Software Tools and Approaches for Compound Identification of LC-MS/MS Data in Metabolomics
by: Ivana Blaženović, et al.
Published: (2018-05-01)

Filtering procedures for untargeted LC-MS metabolomics data
by: Courtney Schiffman, et al.
Published: (2019-06-01)

Characterising Alzheimer's disease through integrative NMR- and LC-MS-based metabolomics
by: Jonas Ellegaard Nielsen, et al.
Published: (2021-12-01)

CSF T-Tau/Aβ42 predicts white matter microstructure in healthy adults at risk for Alzheimer's disease.
by: Barbara B Bendlin, et al.
Published: (2012-01-01)

Brain metabolomics : a new comprehensive metabolic profiling approach to Alzheimer's disease pathology using LC-MS and GC-MS
by: Ebshiana, Amera Abugiala A.
Published: (2018)

Software and Database Usage on Metabolomic Studies: Using XCMS on LC-MS Data Analysis
by: Mustafa Celebier
Published: (2014-04-01)

Metabolomics in Alzheimer's disease
by: Zubair, Mohammed
Published: (2013)

Integrated LC-MS/MS system for plant metabolomics
by: Yuji Sawada, et al.
Published: (2013-01-01)

INTEGRATED LC-MS/MS SYSTEM FOR PLANT METABOLOMICS
by: Yuji Sawada, et al.
Published: (2013-01-01)

LC-MS/MS applications in Targeted Clinical Metabolomics
by: Hellmuth, Christian
Published: (2014)

DEVELOPMENT AND APPLICATIONS OF HPLC-MS/MS BASED METABOLOMICS
by: Zhong, Fanyi
Published: (2018)

Moderate intensity physical activity associates with CSF biomarkers in a cohort at risk for Alzheimer's disease
by: Lena L. Law, et al.
Published: (2018-01-01)

An Algorithm for Preclinical Diagnosis of Alzheimer's Disease
by: Tapan K. Khan
Published: (2018-04-01)

A UPLC/MS-based metabolomics investigation of the protective effect of ginsenosides Rg1 and Rg2 in mice with Alzheimer's disease
by: Naijing Li, et al.
Published: (2016-01-01)

The Wisconsin Registry for Alzheimer's Prevention: A review of findings and current directions
by: Sterling C. Johnson, et al.
Published: (2018-01-01)

Metabolomics data normalization with EigenMS.
by: Yuliya V Karpievitch, et al.
Published: (2014-01-01)

Application of Metabolomics in Alzheimer’s Disease
by: Jordan Maximillian Wilkins, et al.
Published: (2018-01-01)

The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease
by: Nicholas M. Vogt, et al.
Published: (2018-12-01)

Entorhinal and Transentorhinal Atrophy in Preclinical Alzheimer's Disease
by: Sue Kulason, et al.
Published: (2020-08-01)

Preclinical diagnosis of Alzheimer's disease: Prevention or prediction?
by: Ricardo Nitrini

Organization of GC/MS and LC/MS metabolomics data into chemical libraries
by: DeHaven Corey D, et al.
Published: (2010-10-01)

Selectivity in NMR and LC-MS Metabolomics : The Importance of Sample Preparation and Separation, and how to Measure Selectivity in LC-MS Metabolomics.
by: Elmsjö, Albert
Published: (2017)

Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease
by: Julian M. Gaitán, et al.
Published: (2021-05-01)

GC/MS and LC/MS Based Serum Metabolomic Analysis of Dairy Cows With Ovarian Inactivity
by: Yunlong Bai, et al.
Published: (2021-08-01)

MS Based Metabolomic Application for Fermentation Analysis
by: Jiyoung Kim, et al.
Published: (2011-12-01)

The nonlinear relationship between cerebrospinal fluid Aβ42 and tau in preclinical Alzheimer's disease.
by: Mony J de Leon, et al.
Published: (2018-01-01)

Targeted Metabolomics for Plasma Amino Acids and Carnitines in Patients with Metabolic Syndrome Using HPLC-MS/MS
by: Li-li Gong, et al.
Published: (2020-01-01)

Blood-based molecular biomarkers for Alzheimer’s disease
by: Henrik Zetterberg, et al.
Published: (2019-03-01)

Impact of targeted UPLC-MS/MS metabolomics on chemical and biochemical characterisation of MAPs
by: Martens, Stefan, et al.
Published: (2016-07-01)

Metabolomic and elemental analysis of camel and bovine urine by GC–MS and ICP–MS
by: Syed Rizwan Ahamad, et al.
Published: (2017-01-01)

Structure Elucidation of Unknown Metabolites in Metabolomics by Combined NMR and MS/MS Prediction
by: Rene M. Boiteau, et al.
Published: (2018-01-01)

Lipid Peroxidation Assessment in Preclinical Alzheimer Disease Diagnosis
by: Carmen Peña-Bautista, et al.
Published: (2021-06-01)

Nonvascular retinal imaging markers of preclinical Alzheimer's disease
by: Peter J. Snyder, et al.
Published: (2016-01-01)

Metabolic brain networks in aging and preclinical Alzheimer's disease
by: Katelyn L. Arnemann, et al.
Published: (2018-01-01)

Phenotypic heterogeneity and preclinical change in familial Alzheimer's disease
by: Ryan, N. S.
Published: (2017)

Comparison of different MRI-based morphometric estimates for defining neurodegeneration across the Alzheimer's disease continuum
by: Samantha L. Allison, et al.
Published: (2019-01-01)

Application of OCTA in the detection of retinal microvascular changes in Alzheimer's disease in preclinical stage
by: Yu-Ling Tang, et al.
Published: (2020-07-01)