Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe2O3 nanoparticles towards human tumor cells

Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe2O3 nanoparticles towards human tumor cells

Doxorubicin-conjugated magnetic nanoparticles containing hydrolyzable hydrazone bonds were developed using a non-toxic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) coating, which ensured good colloidal stability in aqueous media and limited internalization by the cells, however, enabled adhesion...

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Bibliographic Details
Main Authors: Zdeněk Plichta, Yulia Kozak, Rostyslav Panchuk, Viktoria Sokolova, Matthias Epple, Lesya Kobylinska, Pavla Jendelová, Daniel Horák
Format: Article
Language:English
Published: Beilstein-Institut 2018-09-01
Series:Beilstein Journal of Nanotechnology
Subjects:
cytotoxicity
doxorubicin
magnetic
nanoparticles
poly[N-(2-hydroxypropyl)methacrylamide]
Online Access:https://doi.org/10.3762/bjnano.9.236

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