Genome-Wide DNA Methylation and Hydroxymethylation Changes Revealed Epigenetic Regulation of Neuromodulation and Myelination in Yak Hypothalamus

Genome-Wide DNA Methylation and Hydroxymethylation Changes Revealed Epigenetic Regulation of Neuromodulation and Myelination in Yak Hypothalamus

Both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are important epigenetic modifications in neurodevelopment. However, there is little research examining the genome-wide patterns of 5mC and 5hmC in brain regions of animals under natural high-altitude conditions. We used oxidative reduce...

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Bibliographic Details
Main Authors: Zhixin Chai, Zhijuan Wu, Qiumei Ji, Jikun Wang, Jiabo Wang, Hui Wang, Chengfu Zhang, Jincheng Zhong, Jinwei Xin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Genetics
Subjects:
DNA methylation
hydroxymethylation
neuromodulation
myelination
hypothalamus
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.592135/full

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