Xylan-oligosaccharides ameliorate high fat diet induced obesity and glucose intolerance and modulate plasma lipid profile and gut microbiota in mice

Xylan-oligosaccharides ameliorate high fat diet induced obesity and glucose intolerance and modulate plasma lipid profile and gut microbiota in mice

In recent years, xylan-oligosaccharides (XOS) have attracted much interest as an alternative sweetener for formulating an anti-obesity diet. The present study combining the plasma metabolic profile and gut microbiota analyses investigated the anti-obesity activity of XOS and the possible mechanism i...

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Main Authors: Chengnan Zhang, Abdullah Abdulaziz Abbod Abdo, Benariba Kaddour, Qiuhua Wu, Liang Xin, Xiuting Li, Guangsen Fan, Chao Teng
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Journal of Functional Foods
Subjects:
Xylan-oligosaccharides
Obesity
Plasma lipid profile
Gut microbiota
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464619305468
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spelling doaj-de23835e05df4833b7e15ca0262430992021-04-30T07:17:37ZengElsevierJournal of Functional Foods1756-46462020-01-0164103622Xylan-oligosaccharides ameliorate high fat diet induced obesity and glucose intolerance and modulate plasma lipid profile and gut microbiota in miceChengnan Zhang0Abdullah Abdulaziz Abbod Abdo1Benariba Kaddour2Qiuhua Wu3Liang Xin4Xiuting Li5Guangsen Fan6Chao Teng7Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China; School of Food and Chemical Engineering, Beijing Technology and Business University, No. 11, Fucheng Road, Beijing 100048, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China; School of Food and Chemical Engineering, Beijing Technology and Business University, No. 11, Fucheng Road, Beijing 100048, China; Department of Food Science and Technology, IBB University, IBB, YemenBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China; School of Food and Chemical Engineering, Beijing Technology and Business University, No. 11, Fucheng Road, Beijing 100048, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China; School of Food and Chemical Engineering, Beijing Technology and Business University, No. 11, Fucheng Road, Beijing 100048, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China; School of Food and Chemical Engineering, Beijing Technology and Business University, No. 11, Fucheng Road, Beijing 100048, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China; Beijing Engineering and Technology Research Center of Food Additives, Beijing 100048, China; School of Food and Chemical Engineering, Beijing Technology and Business University, No. 11, Fucheng Road, Beijing 100048, China; Corresponding author at: Mailing address: Beijing Technology and Business University, No 11 Fucheng Street, Haidian District, Beijing 100048, China.Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China; School of Food and Chemical Engineering, Beijing Technology and Business University, No. 11, Fucheng Road, Beijing 100048, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China; School of Food and Chemical Engineering, Beijing Technology and Business University, No. 11, Fucheng Road, Beijing 100048, ChinaIn recent years, xylan-oligosaccharides (XOS) have attracted much interest as an alternative sweetener for formulating an anti-obesity diet. The present study combining the plasma metabolic profile and gut microbiota analyses investigated the anti-obesity activity of XOS and the possible mechanism in mice. Our results showed that the dietary supplementations with 5% and 10% XOS could significantly slow down the body weight gaining and improve glucose intolerance. Lipidomic analyses revealed an alternation in 31 metabolic molecules, in particular the ceramide and diacylglycerol species, in the plasma, which were associated with the XOS supplement. Furthermore, gut microbiota analysis showed that XOS changed the composition of gut microbiota, leading to an increase in the relative population of genus Bifidobacterium, Lachnospiraceae_NK4A136_group and Roseburia. In conclusion, the XOS supplementation could reduce the progression of obesity, improve glucose intolerance, and change the plasma lipid profile and gut microbiota composition.http://www.sciencedirect.com/science/article/pii/S1756464619305468Xylan-oligosaccharidesObesityPlasma lipid profileGut microbiota
collection DOAJ
language English
format Article
sources DOAJ
author Chengnan Zhang
Abdullah Abdulaziz Abbod Abdo
Benariba Kaddour
Qiuhua Wu
Liang Xin
Xiuting Li
Guangsen Fan
Chao Teng
spellingShingle Chengnan Zhang
Abdullah Abdulaziz Abbod Abdo
Benariba Kaddour
Qiuhua Wu
Liang Xin
Xiuting Li
Guangsen Fan
Chao Teng
Xylan-oligosaccharides ameliorate high fat diet induced obesity and glucose intolerance and modulate plasma lipid profile and gut microbiota in mice
Journal of Functional Foods
Xylan-oligosaccharides
Obesity
Plasma lipid profile
Gut microbiota
author_facet Chengnan Zhang
Abdullah Abdulaziz Abbod Abdo
Benariba Kaddour
Qiuhua Wu
Liang Xin
Xiuting Li
Guangsen Fan
Chao Teng
author_sort Chengnan Zhang
title Xylan-oligosaccharides ameliorate high fat diet induced obesity and glucose intolerance and modulate plasma lipid profile and gut microbiota in mice
title_short Xylan-oligosaccharides ameliorate high fat diet induced obesity and glucose intolerance and modulate plasma lipid profile and gut microbiota in mice
title_full Xylan-oligosaccharides ameliorate high fat diet induced obesity and glucose intolerance and modulate plasma lipid profile and gut microbiota in mice
title_fullStr Xylan-oligosaccharides ameliorate high fat diet induced obesity and glucose intolerance and modulate plasma lipid profile and gut microbiota in mice
title_full_unstemmed Xylan-oligosaccharides ameliorate high fat diet induced obesity and glucose intolerance and modulate plasma lipid profile and gut microbiota in mice
title_sort xylan-oligosaccharides ameliorate high fat diet induced obesity and glucose intolerance and modulate plasma lipid profile and gut microbiota in mice
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2020-01-01
description In recent years, xylan-oligosaccharides (XOS) have attracted much interest as an alternative sweetener for formulating an anti-obesity diet. The present study combining the plasma metabolic profile and gut microbiota analyses investigated the anti-obesity activity of XOS and the possible mechanism in mice. Our results showed that the dietary supplementations with 5% and 10% XOS could significantly slow down the body weight gaining and improve glucose intolerance. Lipidomic analyses revealed an alternation in 31 metabolic molecules, in particular the ceramide and diacylglycerol species, in the plasma, which were associated with the XOS supplement. Furthermore, gut microbiota analysis showed that XOS changed the composition of gut microbiota, leading to an increase in the relative population of genus Bifidobacterium, Lachnospiraceae_NK4A136_group and Roseburia. In conclusion, the XOS supplementation could reduce the progression of obesity, improve glucose intolerance, and change the plasma lipid profile and gut microbiota composition.
topic Xylan-oligosaccharides
Obesity
Plasma lipid profile
Gut microbiota
url http://www.sciencedirect.com/science/article/pii/S1756464619305468
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