Malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumor
Abstract Background Renal transplant recipients have increased risk for developing malignant diseases because of immunosuppression or donor-to-recipient transmission. Malignant rhabdoid tumor (MRT) is a rare, highly aggressive and lethal tumor primarily affecting the kidney of infants and young chil...
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doaj-de20a6a9870d4d0d8e711871a570a9402020-11-25T00:17:37ZengBMCDiagnostic Pathology1746-15962017-12-011211610.1186/s13000-017-0677-5Malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumorJing Xiong0Tiefen Su1Pengcheng Zhu2Qilin Ao3Qiurong Ruan4Guoping Wang5Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background Renal transplant recipients have increased risk for developing malignant diseases because of immunosuppression or donor-to-recipient transmission. Malignant rhabdoid tumor (MRT) is a rare, highly aggressive and lethal tumor primarily affecting the kidney of infants and young children. MRT has not been reported in the renal allograft of an adult recipient after kidney transplantation. Case presentation In this report, a 47-year-old woman who received a kidney transplantation from an infant donor and developed a mass in the transplanted kidney is presented. Pathological examinations revealed a malignant tumor with rhabdoid cells morphologically and the loss of INI1 expression immunohistochemically. The diagnosis of malignant rhabdoid tumor in the transplanted kidney was made. We confirmed that donor-to-recipient malignancy transmission was the cause of MRT in the transplanted kidney by fluorescence in situ hybridization (FISH) and short tandem repeat (STR) analysis. Conclusion To our knowledge, this is the first case of MRT in an adult renal allograft recipient. This report highlights the importance of the criteria for selection of donors to screen possible malignant tumors transmission.http://link.springer.com/article/10.1186/s13000-017-0677-5Malignant rhabdoid tumor (MRT)SMARCB1/INI1Kidney transplantationDonor-to-recipient malignancy transmission |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jing Xiong Tiefen Su Pengcheng Zhu Qilin Ao Qiurong Ruan Guoping Wang |
spellingShingle |
Jing Xiong Tiefen Su Pengcheng Zhu Qilin Ao Qiurong Ruan Guoping Wang Malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumor Diagnostic Pathology Malignant rhabdoid tumor (MRT) SMARCB1/INI1 Kidney transplantation Donor-to-recipient malignancy transmission |
author_facet |
Jing Xiong Tiefen Su Pengcheng Zhu Qilin Ao Qiurong Ruan Guoping Wang |
author_sort |
Jing Xiong |
title |
Malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumor |
title_short |
Malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumor |
title_full |
Malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumor |
title_fullStr |
Malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumor |
title_full_unstemmed |
Malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumor |
title_sort |
malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumor |
publisher |
BMC |
series |
Diagnostic Pathology |
issn |
1746-1596 |
publishDate |
2017-12-01 |
description |
Abstract Background Renal transplant recipients have increased risk for developing malignant diseases because of immunosuppression or donor-to-recipient transmission. Malignant rhabdoid tumor (MRT) is a rare, highly aggressive and lethal tumor primarily affecting the kidney of infants and young children. MRT has not been reported in the renal allograft of an adult recipient after kidney transplantation. Case presentation In this report, a 47-year-old woman who received a kidney transplantation from an infant donor and developed a mass in the transplanted kidney is presented. Pathological examinations revealed a malignant tumor with rhabdoid cells morphologically and the loss of INI1 expression immunohistochemically. The diagnosis of malignant rhabdoid tumor in the transplanted kidney was made. We confirmed that donor-to-recipient malignancy transmission was the cause of MRT in the transplanted kidney by fluorescence in situ hybridization (FISH) and short tandem repeat (STR) analysis. Conclusion To our knowledge, this is the first case of MRT in an adult renal allograft recipient. This report highlights the importance of the criteria for selection of donors to screen possible malignant tumors transmission. |
topic |
Malignant rhabdoid tumor (MRT) SMARCB1/INI1 Kidney transplantation Donor-to-recipient malignancy transmission |
url |
http://link.springer.com/article/10.1186/s13000-017-0677-5 |
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