Malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumor

Abstract Background Renal transplant recipients have increased risk for developing malignant diseases because of immunosuppression or donor-to-recipient transmission. Malignant rhabdoid tumor (MRT) is a rare, highly aggressive and lethal tumor primarily affecting the kidney of infants and young chil...

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Main Authors: Jing Xiong, Tiefen Su, Pengcheng Zhu, Qilin Ao, Qiurong Ruan, Guoping Wang
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Diagnostic Pathology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13000-017-0677-5
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spelling doaj-de20a6a9870d4d0d8e711871a570a9402020-11-25T00:17:37ZengBMCDiagnostic Pathology1746-15962017-12-011211610.1186/s13000-017-0677-5Malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumorJing Xiong0Tiefen Su1Pengcheng Zhu2Qilin Ao3Qiurong Ruan4Guoping Wang5Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyInstitute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background Renal transplant recipients have increased risk for developing malignant diseases because of immunosuppression or donor-to-recipient transmission. Malignant rhabdoid tumor (MRT) is a rare, highly aggressive and lethal tumor primarily affecting the kidney of infants and young children. MRT has not been reported in the renal allograft of an adult recipient after kidney transplantation. Case presentation In this report, a 47-year-old woman who received a kidney transplantation from an infant donor and developed a mass in the transplanted kidney is presented. Pathological examinations revealed a malignant tumor with rhabdoid cells morphologically and the loss of INI1 expression immunohistochemically. The diagnosis of malignant rhabdoid tumor in the transplanted kidney was made. We confirmed that donor-to-recipient malignancy transmission was the cause of MRT in the transplanted kidney by fluorescence in situ hybridization (FISH) and short tandem repeat (STR) analysis. Conclusion To our knowledge, this is the first case of MRT in an adult renal allograft recipient. This report highlights the importance of the criteria for selection of donors to screen possible malignant tumors transmission.http://link.springer.com/article/10.1186/s13000-017-0677-5Malignant rhabdoid tumor (MRT)SMARCB1/INI1Kidney transplantationDonor-to-recipient malignancy transmission
collection DOAJ
language English
format Article
sources DOAJ
author Jing Xiong
Tiefen Su
Pengcheng Zhu
Qilin Ao
Qiurong Ruan
Guoping Wang
spellingShingle Jing Xiong
Tiefen Su
Pengcheng Zhu
Qilin Ao
Qiurong Ruan
Guoping Wang
Malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumor
Diagnostic Pathology
Malignant rhabdoid tumor (MRT)
SMARCB1/INI1
Kidney transplantation
Donor-to-recipient malignancy transmission
author_facet Jing Xiong
Tiefen Su
Pengcheng Zhu
Qilin Ao
Qiurong Ruan
Guoping Wang
author_sort Jing Xiong
title Malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumor
title_short Malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumor
title_full Malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumor
title_fullStr Malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumor
title_full_unstemmed Malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumor
title_sort malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumor
publisher BMC
series Diagnostic Pathology
issn 1746-1596
publishDate 2017-12-01
description Abstract Background Renal transplant recipients have increased risk for developing malignant diseases because of immunosuppression or donor-to-recipient transmission. Malignant rhabdoid tumor (MRT) is a rare, highly aggressive and lethal tumor primarily affecting the kidney of infants and young children. MRT has not been reported in the renal allograft of an adult recipient after kidney transplantation. Case presentation In this report, a 47-year-old woman who received a kidney transplantation from an infant donor and developed a mass in the transplanted kidney is presented. Pathological examinations revealed a malignant tumor with rhabdoid cells morphologically and the loss of INI1 expression immunohistochemically. The diagnosis of malignant rhabdoid tumor in the transplanted kidney was made. We confirmed that donor-to-recipient malignancy transmission was the cause of MRT in the transplanted kidney by fluorescence in situ hybridization (FISH) and short tandem repeat (STR) analysis. Conclusion To our knowledge, this is the first case of MRT in an adult renal allograft recipient. This report highlights the importance of the criteria for selection of donors to screen possible malignant tumors transmission.
topic Malignant rhabdoid tumor (MRT)
SMARCB1/INI1
Kidney transplantation
Donor-to-recipient malignancy transmission
url http://link.springer.com/article/10.1186/s13000-017-0677-5
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