CD161+ CD4+ T Cells Harbor Clonally Expanded Replication-Competent HIV-1 in Antiretroviral Therapy-Suppressed Individuals

CD161+ CD4+ T Cells Harbor Clonally Expanded Replication-Competent HIV-1 in Antiretroviral Therapy-Suppressed Individuals

The latent reservoir continues to be the major obstacle to curing HIV-1 infection. The clonal expansion of latently infected cells adds another layer maintaining the long-term stability of the reservoir, but its mechanism remains unclear. Here, we report that CD161+ CD4+ T cells serve as an importan...

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Bibliographic Details
Main Authors: Xiaomin Li, Zhaoli Liu, Qijuan Li, Ronglin Hu, Lu Zhao, Yanyan Yang, Jiacong Zhao, Zhuoqiong Huang, Hongbo Gao, Linghua Li, Weiping Cai, Kai Deng
Format: Article
Language:English
Published: American Society for Microbiology 2019-10-01
Series:mBio
Subjects:
hiv-1
latent reservoir
cd4+ t cells
cd161
clonal expansion
Online Access:https://doi.org/10.1128/mBio.02121-19

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