Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo

Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo

Abstract Growth factor deficiency in adulthood constitutes a distinct clinical syndrome with significant morbidities including abnormal body composition, reduced energy, affective disturbances, dyslipidemia, and increased cardiovascular risk. Protein replacement therapies using recombinant proteins...

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Bibliographic Details
Main Authors:	Pingdong Tao, Yuanyuan Kuang, Yu Li, Wenping Li, Zibei Gao, Lili Liu, Min Qiang, Zhao Zha, Kun Fan, Peixiang Ma, Jeffrey M. Friedman, Guang Yang, Richard A. Lerner
Format:	Article
Language:	English
Published:	Wiley 2020-08-01
Series:	Advanced Science
Subjects:	combinatorial antibody library full agonists function‐guided selection leptin receptors replacement therapy
Online Access:	https://doi.org/10.1002/advs.202000818

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