DNA Aptamers Targeting BACE1 Reduce Amyloid Levels and Rescue Neuronal Deficiency in Cultured Cells
β-amyloid (Aβ) plays an essential role in the pathogenesis of Alzheimer’s disease (AD). Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is indispensable for Aβ production, and knockout of BACE1 has no overt phenotypes in mouse. Thus, fine modulation of BACE1 may be a safe and effective...
Main Authors: | Jun Xiang, Wen Zhang, Xiao-Fang Cai, Min Cai, Zhong-Hai Yu, Feng Yang, Wen Zhu, Xiang-Ting Li, Ting Wu, Jing-Si Zhang, Ding-Fang Cai |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2019-06-01
|
Series: | Molecular Therapy: Nucleic Acids |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253119300563 |
Similar Items
-
Inhibition of BACE1 Activity by a DNA Aptamer in an Alzheimer's Disease Cell Model.
by: Huiyu Liang, et al.
Published: (2015-01-01) -
Dynamin 1 regulates amyloid generation through modulation of BACE-1.
by: Li Zhu, et al.
Published: (2012-01-01) -
BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus
by: Hailong Hou, et al.
Published: (2017-07-01) -
Bace1 activity impairs neuronal glucose metabolism: rescue by beta-hydroxybutyrate and lipoic acid
by: John A Findlay, et al.
Published: (2015-10-01) -
Snapin-Mediated BACE1 Retrograde Transport Is Essential for Its Degradation in Lysosomes and Regulation of APP Processing in Neurons
by: Xuan Ye, et al.
Published: (2014-01-01)