Anti-Oxidant Activity and Dust-Proof Effect of Chitosan with Different Molecular Weights

• Main Authors: Yong Hyun Lee, So Yeon Park, Jae Eun Park, Byung Ok Jung, Jung Eun Park, Jae Kweon Park, You Jin Hwang
• Format: Article
• Language: English
• Published: MDPI AG 2019-06-01
• Series: International Journal of Molecular Sciences
• Subjects: chitosan; molecular weight; fenton reaction; oxidative cleavage; dust-proof
• Online Access: https://www.mdpi.com/1422-0067/20/12/3085

High molecular weight chitosan (HMWC) was degraded to prepare chitosan with different molecular weight based on the fenton reaction, which can produce aggressive OH-radicals produced from hydrogen peroxide in the presence of catalytic metal ions. The relative molecular weight, anti-oxidant activity, and fine dust removal effect of chitosan hydrolysates were elucidated to define their molecular weight and their potent biological activity. Our results demonstrate that chitosan hydrolysates derived from the hydrolysis of HMWC may possess significant free-radical scavenging activity as good anti-oxidants against the radical scavenging activity of DPPH and ABTS, respectively. Furthermore, chitosan hydrolysates can effectively eliminate fine dust, which may contain some particulate matter (PM) and unknown species of microorganisms from the air, suggesting that our data provide important information for producing air filters, dust-proof masks and skin cleaner for the purpose of human healthcare and well-being.