Ablation of interleukin-19 improves motor function in a mouse model of amyotrophic lateral sclerosis

Ablation of interleukin-19 improves motor function in a mouse model of amyotrophic lateral sclerosis

Abstract Neuroinflammation by activated microglia and astrocytes plays a critical role in progression of amyotrophic lateral sclerosis (ALS). Interleukin-19 (IL-19) is a negative-feedback regulator that limits pro-inflammatory responses of microglia in an autocrine and paracrine manner, but it remai...

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Bibliographic Details
Main Authors: Hiroyasu Komiya, Hideyuki Takeuchi, Yuki Ogawa, Kosuke Suzuki, Akihiro Ogasawara, Keita Takahashi, Yasu-Taka Azuma, Hiroshi Doi, Fumiaki Tanaka
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Molecular Brain
Subjects:
Amyotrophic lateral sclerosis
Astrocyte
Interleukin-19
Microglia
Online Access:https://doi.org/10.1186/s13041-021-00785-8

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