Identification of Pharmacokinetic Markers for Guanxin Danshen Drop Pills in Rats by Combination of Pharmacokinetics, Systems Pharmacology, and Pharmacodynamic Assays

Identification of Pharmacokinetic Markers for Guanxin Danshen Drop Pills in Rats by Combination of Pharmacokinetics, Systems Pharmacology, and Pharmacodynamic Assays

This paper reported a feasibility study strategy of identifying pharmacokinetic (PK) markers for a cardiovascular herbal medicine, Guanxin Danshen drop pill (GDDP). First, quantification analysis revealed the constituent composition in the preparation by high-performance liquid chromatography (HPLC)...

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Bibliographic Details
Main Authors: Hong Yao, Xiaomei Huang, Yunjiao Xie, Xuliang Huang, Yijun Ruan, Xinhua Lin, Liying Huang, Peiying Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Pharmacology
Subjects:
Guanxin Danshen drop pills
cardiovascular herbal medicines
pharmacokinetic marker
systems pharmacology
pharmacokinetics
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01493/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01493/full

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