Genistein Ameliorates Adverse Cardiac Effects Induced by Arsenic Trioxide Through Preventing Cardiomyocytes Apoptosis

Genistein Ameliorates Adverse Cardiac Effects Induced by Arsenic Trioxide Through Preventing Cardiomyocytes Apoptosis

Background/Aims: Arsenic trioxide (As2O3) is a highly effective agent for treatment of acute promyelocytic leukemia (APL). However, consecutively administered As2O3 induces serious adverse cardiac effects, including long QT syndrome (LQTs) and even sudden cardiac death. Previous studies have shown t...

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Bibliographic Details
Main Authors: Yuhua Fan, Chen Wang, Yong Zhang, Pengzhou Hang, Yan Liu, Zhenwei Pan, Ning Wang, Zhimin Du
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-01-01
Series:Cellular Physiology and Biochemistry
Subjects:
Genistein
Arsenic trioxide
QT interval prolongation
Apoptosis
Online Access:http://www.karger.com/Article/FullText/343351

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