Interferon gamma activated macrophages kill mycobacteria by nitric oxide induced apoptosis.
Mycobacterium tuberculosis is an intracellular pathogen of macrophages and escapes the macrophages' bactericidal effectors by interfering with phagosome-lysosome fusion. IFN-γ activation renders the macrophages capable of killing intracellular mycobacteria by overcoming the phagosome maturation...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-05-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3085516?pdf=render |