The ubiquitination code: a signalling problem

The ubiquitination code: a signalling problem

<p>Abstract</p> <p>Ubiquitin is a highly versatile post-translational modification that controls virtually all types of cellular events. Over the past ten years we have learned that diverse forms of ubiquitin modifications and of ubiquitin binding modules co-exist in the cell, givi...

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Main Authors: Penengo Lorenza, Sigismund Sara, Woelk Tanja, Polo Simona
Format: Article
Language:English
Published: BMC 2007-03-01
Series:Cell Division
Online Access:http://www.celldiv.com/content/2/1/11
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spelling doaj-ddc7124a012049de889d27f0c7d56bc52020-11-25T00:03:09ZengBMCCell Division1747-10282007-03-01211110.1186/1747-1028-2-11The ubiquitination code: a signalling problemPenengo LorenzaSigismund SaraWoelk TanjaPolo Simona<p>Abstract</p> <p>Ubiquitin is a highly versatile post-translational modification that controls virtually all types of cellular events. Over the past ten years we have learned that diverse forms of ubiquitin modifications and of ubiquitin binding modules co-exist in the cell, giving rise to complex networks of protein:protein interactions. A central problem that continues to puzzle ubiquitinologists is how cells translate this myriad of stimuli into highly specific responses. This is a classical signalling problem. Here, we draw parallels with the phosphorylation signalling pathway and we discuss the expanding repertoire of ubiquitin signals, signal tranducers and signalling-regulated E3 enzymes. We examine recent advances in the field, including a new mechanism of regulation of E3 ligases that relies on ubiquitination.</p> http://www.celldiv.com/content/2/1/11
collection DOAJ
language English
format Article
sources DOAJ
author Penengo Lorenza
Sigismund Sara
Woelk Tanja
Polo Simona
spellingShingle Penengo Lorenza
Sigismund Sara
Woelk Tanja
Polo Simona
The ubiquitination code: a signalling problem
Cell Division
author_facet Penengo Lorenza
Sigismund Sara
Woelk Tanja
Polo Simona
author_sort Penengo Lorenza
title The ubiquitination code: a signalling problem
title_short The ubiquitination code: a signalling problem
title_full The ubiquitination code: a signalling problem
title_fullStr The ubiquitination code: a signalling problem
title_full_unstemmed The ubiquitination code: a signalling problem
title_sort ubiquitination code: a signalling problem
publisher BMC
series Cell Division
issn 1747-1028
publishDate 2007-03-01
description <p>Abstract</p> <p>Ubiquitin is a highly versatile post-translational modification that controls virtually all types of cellular events. Over the past ten years we have learned that diverse forms of ubiquitin modifications and of ubiquitin binding modules co-exist in the cell, giving rise to complex networks of protein:protein interactions. A central problem that continues to puzzle ubiquitinologists is how cells translate this myriad of stimuli into highly specific responses. This is a classical signalling problem. Here, we draw parallels with the phosphorylation signalling pathway and we discuss the expanding repertoire of ubiquitin signals, signal tranducers and signalling-regulated E3 enzymes. We examine recent advances in the field, including a new mechanism of regulation of E3 ligases that relies on ubiquitination.</p>
url http://www.celldiv.com/content/2/1/11
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AT sigismundsara ubiquitinationcodeasignallingproblem
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